Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death
نویسندگان
چکیده
منابع مشابه
Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death.
BACKGROUND Previously, we showed that a mouse model (ACE8/8) of cardiac renin-angiotensin system activation has a high rate of spontaneous ventricular tachycardia and sudden cardiac death secondary to a reduction in connexin43 level. Angiotensin-II activation increases reactive oxygen species (ROS) production, and ACE8/8 mice show increased cardiac ROS. We sought to determine the source of ROS ...
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Cardiac arrhythmia is a common and often lethal manifestation of many forms of heart disease. Gap junction remodeling has been postulated to contribute to the increased propensity for arrhythmogenesis in diseased myocardium, although a causative role in vivo remains speculative. By generating mice with cardiac-restricted knockout of connexin43 (Cx43), we have circumvented the perinatal lethal d...
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Athough it is difficult to determine the precise number, the range for the number of sudden cardiac deaths (SCDs) per year in the United States alone has been reported from 184 000 to 462 000,1 with estimates that 50% to 70% are due to tachyarrhythmic mechanisms. Regardless of where within this range the true number lies, this represents a large epidemiological problem that warrants serious att...
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ژورنال
عنوان ژورنال: Circulation: Arrhythmia and Electrophysiology
سال: 2013
ISSN: 1941-3149,1941-3084
DOI: 10.1161/circep.112.976787